Alzheimer disease,AD
Conditions
Interventions
Vagus nerve electrical stimulation treatment group:vagus nerve electrical stimulation
Sponsors
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The MMSE score was 20 points, in line with the diagnostic criteria for AD-derived MCI established by NIA-AA.
Exclusion criteria
Exclusion criteria: Patients with MCI caused by other causes (such as Parkinson's disease, cerebrovascular disease, lewy body disease, autoimmune encephalopathy, etc.); A history of substance abuse or drug or alcohol dependence within the past 1 year. Patients with severe neuropsychiatric illness or a history of severe neurological illness or brain trauma or brain surgery. Have a serious underlying or physical illness or illness that may affect the assessment (e.g. hearing, visual impairment, etc.). Intracranial stents, pacemakers, coronary stents, cochlear implants and other implantable metal materials were installed. Currently participating in clinical trials of other drugs or medical devices. Patients taking lencanizumab; Patients who refuse to sign informed consent forms. Other conditions deemed unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygen, deoxygenation and hemoglobin content collected by fNIRS(functional Near-Infrared Spectroscopy);Montreal Cognitive Assessment(MoCA)Beijing Version; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental state examination(MMSE); | — |
Countries
China
Contacts
Public ContactTanghuidong
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed