depression
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Depression : meeting the diagnostic criteria of depression in DSM-V ; male or female subjects aged 18-60 years ( including the cut-off value ), of Han nationality ; hamilton Depression Scale ( HAMD ) score >= 18 points ; patients with first-episode depression were treated with psychiatric drugs for less than 2 weeks before admission ; the course of disease in patients with acute recurrence = 60 points ; patients with first-episode schizophrenia were treated with psychiatric drugs for less than 2 weeks before admission ; the course of disease in patients with acute recurrence <= 10 years ; 17.5 <= BMI <= 30 ; can cooperate to complete the questionnaire and sample collection ; signed informed consent form; 3.Healthy controls : aged 18-60 years, Han nationality ; can cooperate to complete the questionnaire and sample collection ; 17.5 <= BMI <= 30 ; signed informed consent form;
Exclusion criteria
Exclusion criteria: 1.Pregnant, lactating women or planned pregnancy; 2.patients with severe physical diseases, including brain organic diseases, congestive heart failure, liver and kidney failure, cancer, immune and metabolic endocrine diseases or hepatobiliary, gastrointestinal diseases, abdominal pain, diarrhea ( except functional constipation ), can refer to the laboratory abnormal indicators higher than the normal value of more than 2 times or combined with the research doctor 's opinion; 3.patients with acute and chronic infections, taking probiotics, anti-inflammatory drugs ( including steroids and non-steroidal drugs, such as aspirin, acetaminophen, ibuprofen, dexamethasone, prednisone, metronidazole, etc. ), and patients who had received antibiotic treatment for three consecutive days in the past month; 4.participants who participated in any clinical trial within 30 days before baseline; 5.meet the diagnostic criteria for other mental disorders in DSM-V ( patients with personality disorders and mental retardation ); 6.the researchers believe that there are situations that do not meet the clinical study, or that the compliance cannot meet the follow-up requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal metagenome;Fecal metabolome;Plasma metabolome;Fecal metatranscriptome; | — |
Countries
China
Contacts
Public ContactFeng Zhu
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed