Acute Ischemic Stroke
Conditions
Interventions
Conventional blood pressure management group:Use antihypertensive medications or observation to ensure SBP <=180 mmHg
Perfusion-based blood pressure management group:Use of antihypertensive or vasopressor drugs, a) SBP 120-140 mmHg in hyperperfused patients
b) SBP 140-180 mmHg in hypoperfused patients
c) SBP <=180 mmHg in patients with normal perfusion
Sponsors
Chengdu Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with acute ischemic stroke within 24 hours of the onset of the anterior circulation (internal carotid and middle cerebral artery M1/M2) in accordance with mechanical thrombectomy; 2. Age>=18 years; 3. Successful recanalization of blood vessels after MT (mTICI grade reaches 2b: reperfusion 50%-90%; 2c: reperfusion 90%-99%; 3: complete reperfusion); 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients are unlikely to benefit from treatment as judged by the clinician responsible for treatment (e.g., advanced dementia or a high probability of death within 24 hours after endovascular thrombectomy); 2. Has another medical condition that would interfere with outcome assessment and follow-up (e.g., known severe pre-stroke disability, a score of 3-5 on the mRS, advanced cancer, or dialysis due to renal failure); 3. Specific contraindications to any antihypertensive drugs used; 4. Have heart disease such as heart failure (ejection fraction <30%), aortic stenosis or arteriovenous shunt; 5. Pregnant women are lactating; 6. Patients participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Based on 90-day mRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICH Intracranial Hemorrhage;Malignant cerebral hematoma;Three months after surgery, all causes of death, disability, or severe disability;Quality of life 3 months after surgery; | — |
Countries
China
Contacts
Public ContactXin Ding
Chengdu Second People's Hospital
Outcome results
None listed