painless gastroenteroscopy
Conditions
Interventions
0.01mg/kg Oliceridine group:Intravenous 0.01mg/kg Oliceridine
0.015mg/kg Oliceridine group:Intravenous 0.015mg/kg Oliceridine
0.02mg/kg Oliceridine group:Intravenous 0.02mg/kg Oliceridine
0.1ug/kg sufentanil group:Intravenous 0.1ug/kg sufentanil
Sponsors
Wenzhou Medical University Lishui Hospital, Lishui People's Hospital, Lishui, Zhejiang 323000, China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.patients undergoing elective painless gastroenteroscopy; 2.18 to 65 years old; 3.American Society of Anaesthesiologists (ASA) classification I to II; 4.cardiac function I or II; 5.BMI 18 to 28 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. patients with contraindications to routine endoscopic procedures or who refuse sedation; 2. history of severe neurological and cardiac, pulmonary, cerebral, and renal diseases (e.g., gastroesophageal reflux, uncontrolled hypertension, diabetes mellitus, and heart disease); 3. acute upper gastrointestinal bleeding with shock; 4. severe anaemia; 5. Gastrointestinal obstruction with retention of gastric contents; 6. long-term drug dependence and psychiatric patients; 7. severe liver function abnormalities; 8. subjects judged to have difficulty with respiratory management with a Modified Mars Score of IV; 9. known or suspected hypersensitivity or contraindication to various components of the study drug, opioids, propofol, etc; 10. those who have participated as a subject in any clinical trial within 3 months prior to enrolment; 11. other conditions judged by the investigator to be unsuitable for enrolment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;heart rate;SpO2;Sedation score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dosage of propofol;Induction time;Gastroenteroscopy time;awakening time;out-of-home time;Intraoperative and postoperative adverse reactions;VAS pain score;satisfaction rating; | — |
Countries
China
Contacts
Public ContactXu Qiaomin
Wenzhou Medical University Lishui Hospital, Lishui People's Hospital, Lishui, Zhejiang 323000, China
Outcome results
None listed