drug-resistant epilepsy
Conditions
Interventions
Grouping according to clobazam exposure level (continuous variables):It was a cohort study without intervention.
Sponsors
Children’s Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: 1. The age of the enrolled patients ranged from 1 month to 18 years. 2. Diagnosis of drug-resistant epilepsy. 3. Enrolled patients have already been treated with clobazam or newly treated with clobazam for antiepileptic therapy. 4. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. The type or dose of combined antiepileptic drugs still needs to be adjusted except clobazam. 2. Moderate to severe liver dysfunction (ALT/AST > 3 times the upper limit of normal). 3. Participants with renal failure requiring dialysis or expected to require dialysis during the study period. 4. Patients who could not be followed up regularly. 5. Patients with poor medication compliance. 6. Patients for whom surgical treatment is indicated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of seizure frequency;Types and proportions of adverse events; | — |
Countries
China
Contacts
Public ContactZengyan Zhu
Children’s Hospital of Soochow University
Outcome results
None listed