Targeted neural regulation of different key nodes in the functional connectivity of the healthy hemisphere attention network in VSN patients

Study on the neuromodulation mechanism of visual spatial attention disorder after stroke based on the compensatory effect of the contralateral hemisphere

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500100355

Enrollment

Unknown

Registered

2025-04-08

Start date

2023-09-14

Completion date

Unknown

Last updated

2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

DLPFC-PPC Group:Left DLPFC target iTBS stimulation

DLPFC-PPC Group:Left PPC target rTMS stimulation

DLPFC-PPC Group:Sham stimulation

PPC-PPC Group:Left DLPFC target iTBS stimulation

PPC-PPC Group:Left PPC target rTMS stimulation

PPC-PPC Group:Sham stimulation

DLPFC(1week-3months):Left DLPFC target iTBS stimulation

Sham stimulation(1week-3months):Left DLPFC target iTBS sham stimulation

DLPFC(>3months):Left DLPFC target iTBS stimulation

Sham stimulation(>3months):Left DLPFC target iTBS sham stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Experiment 1: 1 First occurrence of a solitary lesion in the right hemisphere confirmed by CT or MRI; 2 Age range: 18-80 years old; 3 The course of the disease lasts from 1 week to 3 months; ? Right-handed hand; ? The patient is informed and agrees to this study. Experiment 2: 1 First occurrence of a solitary lesion in the right hemisphere confirmed by CT or MRI; 2 Age range: 18-80 years old; 3 The course of the disease > 3 months; 4 Right-handed hand; 5 The patient is informed and agrees to this study. Experiment 1: 1 First occurrence of a solitary lesion in the right hemisphere confirmed by CT or MRI; 2 Age range: 18-80 years old; 3 The course of the disease lasts from 1 week to 12 months; 4 Right-handed hand; 5 The patient is informed and agrees to this study.

Exclusion criteria

Exclusion criteria: 1. Unable to maintain wakefulness and cooperate with clinical examinations; 2. CT or MRI shows multiple strokes or brain injuries, as well as the presence of other neurological disorders, mental illnesses, etc 3. MMSE score<17 points; 4. Severe uncorrectable visual impairment and visual field disorders; 5. Individuals who have recently used tricyclic antidepressants or sedatives; 6. Seizures and history of epilepsy; 7. Individuals with metal implants in the body (such as cochlear implants, pacemakers, intracranial arterial stents, intracranial vascular coils, ventriculoperitoneal shunt tubes, insulin pumps, etc.) or contraindications to magnetic resonance imaging; 8. Obvious aphasia and comprehension impairment.

Design outcomes

Primary

Measure	Time frame
Paper and pencil test scale;Functional magnetic resonance imaging connection strength;	—

Secondary

Measure	Time frame
Event related potential P300 amplitude;	—

Countries

China

Contacts

Public ContactWeiqun Song

Xuanwu Hospital, Capital Medical University

Songwq66@126.com+86 133 9151 6966

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026