Cardioembolic ischemic stroke
Conditions
Interventions
Evaluation of biomarker elevation.:None
The cerebral infarction group
the non-cerebral infarction group:None
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Cross-sectional Study: Inclusion Criteria for Patients with Atrial Fibrillation Who Have Experienced Cerebral Infarction: 1) Age >= 18 years; 2)Diagnosis of paroxysmal, persistent, or permanent atrial fibrillation or atrial flutter confirmed by electrocardiogram or medical history; 3) Presence of acute large vessel occlusion-type cerebral infarction confirmed by imaging and clinical symptoms, with a clinical or imaging diagnosis of cardioembolic stroke. 2.Cross-sectional Study: Inclusion Criteria for Patients with Atrial Fibrillation Without Cerebral Infarction: 1) Age >= 18 years; 2) Diagnosis of paroxysmal, persistent, or permanent atrial fibrillation or atrial flutter confirmed by electrocardiogram or medical history; 3) No history of cerebral infarction or transient ischemic attack. 3.Prospective Cohort Study: Inclusion Criteria: 1) Diagnosis of paroxysmal, persistent, or permanent atrial fibrillation or atrial flutter confirmed by electrocardiogram or medical history; 2) Presence of one or more of the following risk factors: heart failure, hypertension requiring pharmacological treatment, age >= 75 years, diabetes mellitus, history of thrombosis, or female sex.
Exclusion criteria
Exclusion criteria: 1) Other types of cardiac arrhythmias; 2) Severe valvular heart disease identified by echocardiography; 3) History of other cerebral diseases (e.g., cerebral hemorrhage, brain tumors, etc.); 4) Presence of severe systemic diseases (e.g., malignant tumors, severe hepatic or renal dysfunction, etc.); 5) Acute infectious diseases within the past week (e.g., pulmonary infection, appendicitis, etc.); 6) Recent use of immunosuppressive drugs or receipt of immunotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cross-sectional study:Biomarkers that can reflect the specificity of arterial thrombosis in peripheral blood following cerebral infarction.;Prospective cohort study:Incidence of cerebral infarction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cross-sectional study: Comparing differences in immune cell composition between arterial thrombi and peripheral blood in patients with cardioembolic stroke;Prospective cohort study: Development and validation of a comprehensive predictive model for cardioembolic stroke;Cross-sectional study: Comparative analysis of peripheral blood immune cell composition and gene expression profiles between atrial fibrillation patients with and without cerebral infarction; | — |
Countries
China
Contacts
Public ContactZhenhua Zhou
The First Affiliated Hospital of Army Medical University
Outcome results
None listed