Dry eye disease
Conditions
Interventions
Diquafosol sodium ophthalmic solution group:None
Cyclosporine eye drop group:None
Control group:None
Sponsors
Eye & ENT Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria for non dry eye participants: Participants must meet both of the following criteria simultaneously: 1. No history of dry eye disease, no subjective symptoms such as dryness, foreign body sensation, burning sensation, fatigue, discomfort, or visual fluctuations; 2. Simultaneously meet TBUT>10 seconds, Schirmer i test>10 mm/5 minutes, and corneal fluorescein staining negative. Inclusion criteria for dry eye patients: a history of DED, at least one subjective symptom such as dryness, foreign body sensation, burning sensation, fatigue, discomfort, or visual fluctuations, and at least one of the following: 1. Tear film rupture time (TBUT) is less than 5 seconds; 2.The Schirmer I test result is less than 5 mm/5 minutes; 3. TBUT is positive for corneal fluorescein staining (CFS) between 5 and 10 seconds; 4. The Schirmer I test result is positive for CFS between 5 mm/5 minutes and 10 mm/5 minutes.
Exclusion criteria
Exclusion criteria: 1. Allergic to sodium fluorescein; 2. History of eye surgery or trauma in the past 3 months; 3.Less than one month after lacrimal punctum occlusion; 4. Active eye infections in the past month; 5. History of intraocular inflammation or uveitis; 6. History of viral keratitis; 7. Oral antibiotics or topical antibiotic eye drops taken within the past month; 8. Within the past month, oral or topical use of glucocorticoids, nonsteroidal anti-inflammatory drugs, cyclosporine, or immunosuppressants on the ocular surface; 9.Use artificial tears within 24 hours prior to the study; 10. Have used Diquat Sodium Eye Drops or Cyclosporine Eye Drops within one month prior to the stud; 11. Other conditions deemed inappropriate by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| tear break-up time;schirmer-I test;ocular surface disease index;Ligamine green staining of conjunctiva;Determination of ocular surface microbiota;Corneal fluorescein sodium staining; | — |
Countries
China
Contacts
Public ContactGong Lan
Eye & ENT Hospital of Fudan University
Outcome results
None listed