ISS,Idiopathic short stature
Conditions
Interventions
Children with idiopathic short stature treated with recombinant human growth hormone:None
Children with idiopathic short stature who have not been treated with BL-11:NA
Children with idiopathic short stature treated with BL-11:None
Sponsors
West China Second University Hospital of Sichuan University (WCSUH- SCU)
Eligibility
Sex/Gender
All
Age
4 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Those who meet the diagnostic criteria for ISS in the 8th edition of "Zhufutang Practical Pediatrics" (height is more than 2 standard deviations (SD) lower than the reference height of normal children, growth rate is less than 5cm/year, bone age is normal or delayed, and growth hormone peak is not less than 10 µ g/L); 2. Individuals aged 4-12 years old, all in the early stage of puberty (male testicular volume <= 4 mL, female breast development in Tanner stage I); 3.Individuals who have not used corticosteroids, gamma aminobutyric acid, or other related therapeutic drugs within the first 3 months of enrollment; 4.The families of the sick children all agreed to participate in this study.
Exclusion criteria
Exclusion criteria: 1. incomplete clinical data; 2. Lost to follow-up during treatment; 3. Chromosomal abnormalities exist; 4. Suffering from other underlying diseases, such as endocrine system diseases, skeletal system diseases, kidney system diseases, cardiovascular system diseases, genetic metabolic diseases, psychosomatic disorders, malnutrition, etc; 5. Family members or patients refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Height growth during treatment (cm/year); | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum growth factor levels;25 hydroxyvitamin D levels;Adverse reaction incidence rate;Bone metabolism index level;Progress of bone age; | — |
Countries
China
Contacts
Public ContactFan Yang
West China Second University Hospital of Sichuan University (WCSUH- SCU)
Outcome results
None listed