Recurrent pregnancy loss
Conditions
Interventions
Experimental group:Recombinant human granulocyte colony stimulating factor medication
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Recurrent spontaneous abortion: 2 or more consecutive pregnancy losses with the same sexual partner before 24 weeks of pregnancy; 2. Gestation days: 30-45 days (based on the last menstrual period); 3. Natural pregnancy; 4. Diagnosis of pregnancy is based on ultrasound results; 5. Age: 20-35 years old; 6. BMI: 18.5–24 kg/m2;
Exclusion criteria
Exclusion criteria: 1.Those who do not meet the inclusion criteria; 2.Those who refuse to sign informed consent; 3. Chromosomal abnormality in either spouse: The chromosome test result shall prevail; array-CGH in the last miscarriage showed abnormal fetal karyotype; 4.Abnormal uterine anatomical structure: the results of hysteroscopy/B-ultrasound shall prevail; 5.Female infertility: The couple has regular sexual intercourse for 1 year, without contraception and no pregnancy; 6. Endocrine and metabolic abnormalities (1) Hyperprolactinemia: serological test (2) Cushing's syndrome: typical clinical symptoms and signs, such as central obesity, purple lines, increased hair, sexual dysfunction, fatigue, etc. Urinary 17-hydroxycorticosteroid excretion was significantly increased, which could not be inhibited by low-dose dexamethasone suppression test. Elevated blood 11-hydroxycorticosteroid levels and loss of circadian rhythm (3) Premature ovarian failure: oligomenorrhea or amenorrhea for at least 4 months; FSH > 25IU/L twice at random (interval > 4 weeks); 7. Abnormal blood routine: abnormal white blood cells and platelets (before medication); 8. Recent (within 90 days) medication history: excluding folic acid tablets, multivitamin tablets and combined auxiliary medications; 9. Basic diseases of the heart, brain, lung, liver, kidney, etc.: medical history and liver and kidney function, cardiopulmonary function; 10. Abnormal infection indicators: AIDS, syphilis, hepatitis, tuberculosis, secretions, toxoplasmosis, cytomegalovirus, herpes virus; 11. History of malignant tumors; 12.Allergic diseases or allergic constitution: medical history, allergic to any rhG-CSF drug or any E. coli derived protein; 13. Smoking and severe alcoholism;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Embryo survival rate at 20 weeks of gestation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Embryo survival rate at 28 weeks of gestation;Live birth rate;Gestational age at delivery;Embryo survival rate at 12 weeks of gestation;Complications of childbirth; | — |
Countries
China
Contacts
Public ContactPengsheng Zheng
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed