Pain after cesarean section
Conditions
Interventions
Control group:100ug sufentanil citrate was prepared into a 100ml solution using 0.9% sodium chloride injection, a loading dose of 6ug (6ml) was given for the first pain after giving birth, and a PCA d
Treatment group:25mg TRV130 was prepared into a 100ml solution with 0.9% sodium chloride injection, a loading dose of 1.5mg (6ml) was given for the first pain after delivery, and a PCA dose could be u
Sponsors
Lianyungang First People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Age 20-45 years (including the critical value); 2.Preoperative American Society of Anesthesiologists (ASA) Grade II to III; 3.Patients undergoing cesarean section under intravertebral anesthesia; 4.Subjects voluntarily participated in this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients allergic to any drugs used in the study; 2.Patients with a history of chronic pain or long-term use of sedative analgesics; 3.Patients with a history of mental illness or long-term use of psychotropic drugs; 4.Patients with abnormal liver and kidney function; 5.Patients with severe pregnancy complications, such as preeclampsia, placental hyperplasia spectrum, or HELLP syndrome; 6.Patients who are unable to understand and correctly express VAS pain scores; 7.Patients who have participated in other clinical studies within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total pain intensity was poor from 0 to 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The sum of pain intensity differences at 12h, 24h, and 36h;The total number of compressions, the number of effective compressions and the total compression dose of the PCA pump during the 48-hour period;The time of first administration of remedial medication;The proportion of subjects using remedial drugs;The frequency and dosage of using remedial drugs;The proportion of subjects whose treatment failed due to insufficient analgesic effect;The satisfaction scores given by the investigators and the subjects regarding the analgesic treatment were evaluated 48 hours after administration.; | — |
Countries
China
Contacts
Public ContactZhang Xiaobao
Lianyungang First People's Hospital
Outcome results
None listed