Postoperative residual effects of muscle relaxants following laparoscopic surgery
Conditions
Interventions
Standard dosing method ( Group S):The standard administration method of sugammadex sodium relies on a neuromuscular monitoring device. Upon the patients entry into the operating room (at T1 time), sug
1-2 mg/kg when TOFC is 0-4 or TOFR is = 2
and 4 mg/kg when PTC is 1-2.
Empirical Dosing Method (Group E):In Group E, based on the clinical judgment of the PACU physician, 2 mg/kg of sugammadex sodium was administered upon observation of signs such as spontaneous eye open
Sponsors
The Second Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective laparoscopic abdominal surgery under general anesthesia; 2. Age > 18 years old; 3. BMI index 18 - 30 kg/m^2; 4. American Society of Anesthesiologists (ASA) classification grade I to III; 5. Normal cognitive function; 6. Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to participate in the study; 2. Patients with communication barriers or inability to cooperate with researchers due to language comprehension disorders, mental illness, epilepsy, history of Parkinson's disease, myasthenia gravis, or similar conditions; 3. Patients with a confirmed or suspected history of alcohol, analgesic, or other drug abuse and addiction; 4. Patients with preoperative blood pressure >= 180/110 mm Hg (WHO-ISH guideline stage 3 hypertension); 5. Patients who experienced unstable angina pectoris or myocardial infarction within the past 3 months or have a New York Heart Association (NYHA) functional class >= 3; 6. Patients with severe liver dysfunction (ALT, conjugated bilirubin, AST, ALP, or total bilirubin > 2 times the upper limit of normal) or severe kidney dysfunction (creatinine clearance rate 177 µmol/L); 7. Patients who participated in other clinical trials within 3 months prior to enrollment in this study; 8. Patients deemed by the attending physician or researcher as unsuitable for participation in the study due to other reasons (reasons must be documented, e.g., family environment interference); 9. Patients allergic to sugammadex sodium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The TOF and PTC values were recorded at different time points (T1-T9), and the percentage of cases with TOFR > 0.9 at each time point was calculated; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time;PACU stay time;Time to recovery of spontaneous breathing;Incidence of residual neuromuscular blockade caused by muscle relaxants ;The incidence of complications 7 days after surgery;hospital stay time;Arterial blood pressure at each time point from T1 to T9;SPO2 at each time point from T1 to T9;Respiratory rates at time points T1 to T9;Heart rate at each time point from T1 to T9; | — |
Countries
China
Contacts
Public ContactLi Sun
Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University
Outcome results
None listed