Postoperative acute pain
Conditions
Interventions
Intervention Group:The fospropofol disodium group received a continuous intravenous infusion of fospropofol disodium at an initial rate of 12.5 mg/kg/h, with a maximum infusion rate of 15 mg/kg/h.
Control Group:Anesthesia maintenance was achieved with a continuous intravenous infusion of propofol at an initial rate of 6 mg/kg/h, with a maximum infusion rate of 12 mg/kg/h.
Sponsors
Affiliated Hospital of West Anhui Health Vocational College
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Patients aged >=65 years undergoing general anesthesia. (2) American Society of Anesthesiologists (ASA) physical status classification of I-II. (3) Patients scheduled for non-cardiac, non-neurosurgical, and non-hepatobiliary elective surgeries under general anesthesia, with an expected duration of =30 minutes and estimated blood loss of =500 mL.
Exclusion criteria
Exclusion criteria: (1) Patients with a known allergy to fospropofol or fospropofol disodium. (2) Patients with severe hepatic or renal insufficiency or other conditions that may affect the metabolism of anesthetic agents. (3) Patients who have recently used other anesthetic drugs or immunomodulatory agents. (4) Patients with communication barriers, no history of psychiatric or neurological disorders, and no long-term use of sedative medications. (5) Patients with suspected or confirmed history of alcohol or drug abuse. (6) Patients with allergies to any components of the study drug. (7) Patients with cardiopulmonary diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia onset time;Anesthesia recovery time;Anesthesia maintenance time;Immune Function; | — |
Countries
China
Contacts
Public ContactJun Shen
Affiliated Hospital of West Anhui Health Vocational College
Outcome results
None listed