Membranous Nephropathy
Conditions
Interventions
Index test:PLA2R-IgG4
Sponsors
Suzhou Ninth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: This study is a non-randomized controlled clinical trial, and it is estimated that more than 50 patients with IMN nephropathy, more than 100 patients with other immune diseases, and more than 100 normal people will be included in this study according to the scale of our hospital and the number of patients admitted to the Department of Nephrology in previous years. 1. Age: > = 18 years old, < 70 years old, gender is not limited; 2. Newly diagnosed patients and successfully obtained renal pathological diagnosis results; 3. Not receiving immunosuppressant and/or glucocorticoid therapy; 4. Willing and able to understand this study: Able to comply with all elements of the study protocol and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with serious infections, cardiovascular and cerebrovascular diseases and other major comorbidities; 2. Patients with end-stage renal disease (eGFR<15ml/min/1.73m^2). 3. Myocardial infarction, unstable angina, stroke or hospitalization due to heart failure 3 months before the study; 4. Those who participated in other clinical trials within 3 months before the study and received experimental drugs; 5. Those who are pregnant or breastfeeding; 6. Patients with mental abnormalities, intellectual disabilities and other patients who cannot cooperate with the study; 7. Presence of a condition as assessed by the investigator that would interfere with the interpretation of study results, or compromise compliance with study procedures or affect the safety of the subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anti-PLA2R-IgG4;anti-PLA2R-IgG;24-hour urinary protein quantification;Serum Albumin;Serum Creatinine;Renal Pathology; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urinary Albumin-to-Creatinine Ratio (UACR);Triglycerides and Total Cholesterol;Total Cholesterol; | — |
Countries
Chian
Contacts
Public ContactXu Yan
Suzhou Ninth People's Hospital
Outcome results
None listed