PSCI
Conditions
Interventions
PSCI Group:Medication treatment + conventional cognitive function training
Non-PSCI group:NA
Sponsors
Shanghai University of Medicine & HealthScienceAffiliated Zhoupu Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Age range: The inclusion criteria are set for ages 55 to 95 years. 2. Stroke diagnosis: The inclusion criteria include patients with a history of ischemic or hemorrhagic stroke for more than 6 months, confirmed by brain imaging (e.g., cranial CT or MRI). 3. Cognitive impairment diagnosis: The inclusion criteria require a clear clinical diagnostic standard for cognitive impairment, such as DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) or NINDS-AIREN (National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l'Enseignement en Neurosciences criteria for vascular dementia). 4. Cognitive function assessment: Use standardized cognitive assessment tools (e.g., MMSE or MoCA) for evaluation, with inclusion criteria requiring patients’ scores to meet the diagnostic standards for cognitive impairment. 5. Non-targeted metabolomics data collection: Specify the type of biological samples to be collected (e.g., blood, feces) and the time points for collection to facilitate metabolomics analysis. 6. Consent to participate: The inclusion criteria require patients to understand the purpose and procedures of the study and to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Other neurological diseases: Exclude patients diagnosed with other confirmed neurological disorders such as Alzheimer’s disease, Parkinson’s disease, or frontotemporal dementia to ensure that the primary cause of cognitive impairment in the study subjects is post-stroke cognitive impairment (PSCI). 2. Severe organic brain lesions: Exclude patients with severe organic brain lesions, such as intracranial space-occupying lesions or intracranial hemorrhage, to avoid interference from other lesions on cognitive impairment. 3. Cardiovascular diseases: Exclude patients with other severe cardiovascular diseases, such as myocardial infarction or heart failure, to reduce the impact of cardiovascular factors on cognitive function. 4. Severe psychiatric disorders: Exclude patients with significant mental illnesses, such as severe depression or severe anxiety, to ensure that cognitive impairment is caused by stroke. 5. Severe liver or kidney dysfunction: Exclude patients with significant liver or kidney dysfunction to avoid their influence on metabolomics analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| minimental status evaluation, MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Activities of Daily Living scale;fNIRS;Montreal cognitive assessment,MoCA; | — |
Countries
China
Contacts
Public ContactZhou Yumin
Shanghai University of Medicine &HealthScienceAffiliated Zhoupu Hospital
Outcome results
None listed