MASLD
Conditions
Interventions
lean non-MASH group:None
lean MASH group:None
Overweight/obese non-MASH group:None
Overweight/obese MASH group:None
Sponsors
Zhongshan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged > = 18 years old and < = 80 years old; 2. Risk of NASH, such as obesity, diabetes, metabolic syndrome, or chronic elevated serum aminotransferase concentration; 3. No other acute or chronic illness other than obesity, type 2 diabetes mellitus, or metabolic syndrome based on medical history, physical and laboratory tests.
Exclusion criteria
Exclusion criteria: 1. Excessive alcohol consumption (excessive alcohol intake is defined as > 210 grams per week for men and >140 grams per week for women); 2. Liver diseases other than MASLD/MASH (including hepatitis B or C, autoimmune hepatitis, etc.); 3. Use hepatoprotective drugs such as silymarin and phosphatidylcholine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver proteomic/phosphoproteomic profiles ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver transcriptome;Genetic background (SNPs);Serum metabolomic profiles;Serum proteomic profiles;All-cause and cause-specific mortality; | — |
Countries
China
Contacts
Public ContactMingfeng Xia
Zhongshan Hospital Fudan University
Outcome results
None listed