Effects of Low-Dose Esketamine Combined with Propofol Sedation on Respiratory Depression and Hypotension in Elderly Patients Undergoing Painless Gastrointestinal Endoscopy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500100262

Enrollment

Unknown

Registered

2025-04-07

Start date

2025-04-15

Completion date

Unknown

Last updated

2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Esketamine + propofol group:The patient first received ?intravenous (IV) sedation induction? with ?Fentanyl 1 µg/kg? and ?Propofol 0.5 mg/kg?, followed by ?Esketamine 0.2 mg/kg IV?. Anesthetic depth w

propofol group:The patient received ?initial sedation induction? via intravenous (IV) administration of ?Fentanyl 1 µg/kg? and ?Propofol 0.5 mg/kg?, followed by an ?equivalent volume of normal saline

Eligibility

Sex/Gender

All

Age

60 Years to 79 Years

Inclusion criteria

Inclusion criteria: ?1. Age?: 60–79 years; ?2. ASA Physical Status?: Class I–II (American Society of Anesthesiologists classification); ?3. Body Mass Index (BMI)?: 18–30 kg/m²; 4. Elderly patients scheduled for elective combined painless gastroscopy and colonoscopy; 5. Willingness to adhere to the study protocol and provision of voluntarily signed informed consent.

Exclusion criteria

Exclusion criteria: 1?. Severe Cardiopulmonary Disease?: Uncontrolled severe hypertension , severe arrhythmias, unstable angina, acute respiratory infections, or active asthma exacerbation . ?2. Major Organ Dysfunction or Emergencies?: Severe hepatic dysfunction or renal insufficiency ; Acute upper gastrointestinal bleeding with hemodynamic shock ;Severe anemia ;Gastrointestinal obstruction with gastric retention . 3?. Patients without a responsible escort or legally authorized representative to provide consent. ?4. History of hypersensitivity to sedatives/anesthetics or known allergy to esketamine or its excipients. 5. Acute alcohol intoxication ; Preoperative use of sedatives, opioids, or analgesics . ?Neurological/Psychiatric Comorbidities?: 6. Neurocognitive disorders; Active psychiatric conditions; History of seizure disorders or EEG-confirmed epileptiform activity.

Design outcomes

Primary

Measure	Time frame
Incidence of respiratory depression and hypotension (respiratory depression, hypotension, or both) during sedation.;	—

Countries

China

Contacts

Public ContactQin Liu

Suining Central Hospital

924676749@qq.com+86 151 8355 4127

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026