Effects of Different Folic Acid Supplementation Doses on Subsequent Pregnancy Outcomes in Women with a History of Pregnancy Loss: A Multicenter Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500100255

Enrollment

Unknown

Registered

2025-04-07

Start date

2025-04-10

Completion date

Unknown

Last updated

2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pregnancy loss

Interventions

Intervention group:800 µg folic acid/day (2 tablets× 400 µg)

Control group:400 µg folic acid/day (1 tablet× 400 µg)

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Have a history of > = 1 pregnancy loss, and present to the reproductive center with a positive serum hCG; Age 18-40 years; Voluntarily signed informed consent; BMI 18.5-28 kg/m².

Exclusion criteria

Exclusion criteria: thyroid disease; antiphospholipid antibody syndrome (APS); abnormal uterine anatomy; Chromosomal abnormalities in couples

Design outcomes

Secondary

Measure	Time frame
early pregnancy loss rate;Continuous pregnancy rate (24 weeks);incidence rate of pregnancy complications;neonatal birth weight;Incidence of adverse event;	—

Primary

Measure	Time frame
live birth rate;Homocysteine reduction;	—

Countries

China

Contacts

Public ContactWang Fang

The second hospital of Lanzhou University

ery_fwang@lzu.edu.cn+86 139 1930 2888

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026