None
Conditions
Interventions
GnRHa-HRT Group:GnRHa-HRT protocol
Frozen-thawed single blastocyst transfer
HRT Group:HRT protocol
Sponsors
Hospital Reproductive Medicine Affiliated to ShanDong University
Eligibility
Sex/Gender
Female
Age
No minimum to 38 Years
Inclusion criteria
Inclusion criteria: 1.Women with a history of RIF, RIF refers to failure to achieve a clinical pregnancy after one of the following conditions with all embryos transferred being of good quality: 3 or more embryo transfer cycles; 2 embryo transfer cycles where no less than three embryos were transferred cumulatively. 2.Women with at least 1 good-quality blastocysts on day 5 or day 6 of embryo for frozen-thawed single blastocyst transfer in IVF/ICSI cycles. 3.Women under the age of 38 years at oocyte retrieval. 4.Women with signed informed consents.
Exclusion criteria
Exclusion criteria: 1.Women with known uterine or endometrial pathologies, such as uterine malformation, intrauterine adhesions, hydrosalpinx, endometriosis, or adenomyosis. 2.Women with cycle cancellation due to thin endometrium (<7 mm) during the endometrium preparation process in previous frozen embryo transfer cycles. 3.Women with infectious diseases, autoimmune diseases and metabolic diseases, which were known to cause implantation failure. 4.Women with =2 previous miscarriages. 5.Women who use donated oocytes or sperm to achieve pregnancy, or transfer embryo after multiple vitrification-warming procedures. 6.Women with contraindications for the use of estrogen and progesterone drugs, such as history of breast cancer, risk of thrombosis, etc. 7.Women with medical contraindications to assisted reproductive technology and/or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy loss rate;Clinical pregnancy rate;Onging pregnancy rate;Biochemical pregnancy loss rate;Birth weight;Good live birth rate;Biochemical pregnancy rate;Maternal complication rate;Neonatal complication rate; | — |
Countries
China
Contacts
Public ContactQian Zhang
Hospital Reproductive Medicine Affiliated to ShanDong University
Outcome results
None listed