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Efficacy and mechanism of rPMS combined with iTBS closed-loop mode in the treatment of upper limb spasm after stroke

Efficacy and mechanism of rPMS combined with iTBS closed-loop mode in the treatment of upper limb spasm after stroke

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500100209
Enrollment
Unknown
Registered
2025-04-03
Start date
2024-02-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

Group A:3min20s iTBS combined with 30min rPMS
Group B:3min20s Sham-iTBS combined with 30min rPMS
Group C:3min20s iTBS combined with 30min Sham-rPMS
Group D:3min20s Sham-iTBS combined with 30min Sham-rPMS

Sponsors

Hangzhou linping hospital of traditional Chinese and Western medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of stroke revised by the 8th National Conference on Cerebrovascular Disease in 2022, and confirmed by head CT or MRI examination 2. Upper limb and hand spasm caused by first episode of cerebral hemorrhage or cerebral infarction, modified AShworth score >=1 3. Onset time of 1 ~6 months 4. The patients aged 30-80 years old were in stable condition. 5. No severe cognitive and communication disorders 6. Sign informed consent

Exclusion criteria

Exclusion criteria: 1. with severe heart, liver, kidney and other important organ dysfunction 2. with other nervous system diseases (craniocerebral trauma, Parkinson's disease, increased intracranial pressure) 3. Disturbance of consciousness (GCS < 15 points) 4. Patients with cardiac pacemaker, cochlear implant or skull repair surgery 5. previous seizures and unexplained convulsion.

Design outcomes

Primary

MeasureTime frame
modified Barthel index;modified Ashworth scale;Fugl-Meyer Assessment of Upper limb motor function scale;

Secondary

MeasureTime frame
Surface electromyography;

Countries

China

Contacts

Public ContactLijuan Xu

Hangzhou linping hospital of traditional Chinese and Western medicine

18257119252@163.com+86 182 5711 9252

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026