Colorectal cancer
Conditions
Interventions
Control group (Group OA):The application of sufentanil and remifentanil
Control group (Group OFA):Application of dexmedetomidine, esketamine and flurbiprofen axetil
Sponsors
First Affiliated Hospital of Gannan Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. FRAIL Frailty Scale score>=3 points; 2. Age>=60 years; 3. ASA Grading II.-III; 4. Patients undergoing elective laparoscopic colorectal cancer surgery in our hospital; 5. Body mass index (BMI) 18~28 kg/m^2; 6. Those who agree to participate in this study and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Inability to provide informed consent before surgery; 2. Acute or chronic pain or long-term use of opioids or non-steroidal drugs; 3. Patients with severe bradycardia (preoperative heart rate<50bpm) or patients with abnormal cardiac conduction and rhythm; 4. Patients with severe diseases of major organs such as heart, brain, lung, liver, and kidney; 5. Patients who are allergic to the study drug; 6. Those with a history of mental illness, language and communication disorders, hearing impairment, and inability to understand the content of the test;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The quality of postoperative recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| time for the first bed activity after surgery;Incidence of Agitation in the Awakening Period;Intraoperative hemodynamic monitoring indicators;Number of days in hospital after surgery;Time of tracheal extubation;The incidence of postoperative adverse reactions;Time to water for the first time after surger;The number of postoperative analgesic pump compressions;Postoperative pain;Incidence of postoperative delirium;Length of Postanesthesia care unit stay;time of first flatus after surgery;The occurrence of intraoperative adverse events (hypotension, hypertension, sinus bradycardia) was recorded;Number and dosage of postoperative analgesic drug remedies;The incidence of hypoxemia in Postanesthesia care unit;Time to eat for the first time after surger;Patient baseline data; | — |
Countries
China
Contacts
Public ContactShihong Li
First Affiliated Hospital of Gannan Medical University
Outcome results
None listed