Bronchiolitis obliterans after lung transplantation
Conditions
Interventions
Gold Standard:According to the histopathological diagnostic criteria for bronchiolitis obliterans published by ISHLT in 2007, respiratory bronchiolitis is characterized by dense eosinophilic fibrosis
Index test:Morphological measurement and evaluation of image data under pCLE, collecting quantitative data including median cell count per microscopic field, cell spontaneous fluorescence units, cell
Sponsors
Wuxi People’s Hospital Affiliated to Nanjing Medical
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Postoperative follow-up recipients; (2) Patients with symptoms such as increased respiratory secretions, cough and sputum, dyspnea, hemoptysis, etc.; (3) recipients with progressive decline in lung function; (4) Lung imaging (chest CT or chest X-ray) shows the emergence of new lesions or progressive exudative foci in the lungs.
Exclusion criteria
Exclusion criteria: (1) Unstable vital signs; (2) Consciousness disorders, cerebrovascular accidents, stroke; (3) Septic shock/ARDS; (4) Acute coronary syndrome; (5) Recently, there has been severe hemoptysis; (6) Severe bleeding tendency; (7) Smoking; (8) Severe impairment of lung function, accompanied by severe hypoxemia, and inability to tolerate bronchoscopy examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median cell count per microscopic field of view;Diameter of respiratory bronchioles; | — |
Countries
China
Contacts
Public ContactBo Wu
Wuxi People’s Hospital Affiliated to Nanjing Medical
Outcome results
None listed