Alzheimers disease
Conditions
Interventions
Alzheimers disease with epilepsy:None
Alzheimers disease without epilepsy:None
Epilepsy without Alzheimers disease:None
Sponsors
Shanghai Geriatric Medical Center
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age >=50 years and<= 80 years, with no gender restriction; 2.Clinical diagnosis of dementia according to DSM-V criteria, or diagnosis of epilepsy according to ILAE criteria; 3.Signed informed consent form;
Exclusion criteria
Exclusion criteria: 1.Dementia diagnosed as being caused by conditions other than Alzheimer's disease,such as vascular dementia, frontotemporal dementia, or Lewy body dementia; 2.Presence of severe anxiety or depression (PHQ-9 score >= 20 or GAD-7 >= 19), psychiatric disorders, or inability to cooperate with cognitive function tests; 3.Presence of acute progressive systemic diseases, severe cardiopulmonary insufficiency, malignancies, or pregnancy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence rate of new-onset epilepsy;Expression of INPP5D gene;Incidence rate of new-onset Alzheimer's disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor-alpha (TNF-a) level;Epileptiform discharge rate;Interleukin-6 (IL-6) level;TREM2 expression level;Cognitive status; | — |
Countries
China
Contacts
Public ContactWeifeng Peng
Shanghai Geriatric Medical Center
Outcome results
None listed