postoperative delirium
Conditions
Interventions
Permissive hypercapnia group:The range of tidal volume was 6-8 mL/kg, respiratory rate 12-14 times /min, I:E=1:2, PaCO2 45-55 mm Hg, pH 7.20-7.35.
Conventional ventilation group (R group):Tidal volume ranged from 10 to 12 ml /kg, respiratory rate from 14 to 16 times /min, I:E=1:2, PaCO2 from 35 to 45 mmHg, pH from 7.35 to 7.45
Sponsors
Yantai Affiliated Hospital of Binzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) >= 65 years old. (2) American Society of Anesthesiologists (ASA) classification II–III. (3) The expected length of hospital stay is more than 3 days. (4)The patient or the family member signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1)The preoperative Montreal Cognitive Assessment (MoCA) score ? or LVEF < 30%), respiratory function, liver and kidney dysfunction. (3) poorly controlled diabetes and hypertension. (4) patients who are expected to need postoperative intubation and thus unable to perform cognitive assessment; (5) patients who were allergic to or had contraindications to the drugs used during the study; (6) patients who participated in other drug trials within 1 month before planned surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Montreal Cognitive Assessment (MoCA) score.;Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Score;Cerebral oxygen saturation,Mean arterial pressure, arterial partial pressure of carbon dioxide, heart rate, and lactic acid;Pain;Vomiting;Length of PACU stay;Infusion volume, urine volume, blood loss volume, dosage of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactHuang Lanji
Yantai Affiliated Hospital of Binzhou Medical University
Outcome results
None listed