Neuromyelitis spectrum disease
Conditions
Interventions
Acute stage group:No intervention
Remission stage group:No intervention
Healthy control group:No intervention
Sponsors
Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.NMOSD diagnosis conforms to the 2015 NMOSD International Consensus Diagnostic Criteria; 2. The time from admission to the collection of blood samples was less than 24 hours, and before the collection of blood samples, the patients in the acute stage group had not received excessive dose of hormone shock, plasma exchange or immunoglobulin treatment within 2 weeks, and the current treatment regimen had not been adjusted within 2 weeks before the collection of blood samples in the remission stage; 3. Complete clinical data including gender, age, inducement, underlying disease, clinical symptoms, skull and spinal cord NMR, AQP-4 antibody and other baseline data in all groups.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of infection within the last 1 month; 2. Combined with other autoimmune diseases; 3. Patients with other severe neurological diseases; 4. Patients with cardiopulmonary or liver and kidney diseases; 5. Patients with malignant tumors; 6. Immunoglobulin and plasma exchange were performed before blood collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of interleukin 6 in peripheral blood;The amount of interleukin 2 in peripheral blood;The amount of interleukin 10 in peripheral blood;The number of follicular helper T cells in peripheral blood;The number of memory B cells in peripheral blood;Regulatory B cells; | — |
Countries
China
Contacts
Public ContactYa Chen
Affiliated Hospital of Zunyi Medical University
Outcome results
None listed