Chronic obstructive pulmonary disease with severe community-acquired pneumonia
Conditions
Interventions
Hypocapnia group , normal blood capnia group , hypercapnia group :None
Sponsors
Shuangliu District First People’s Hospital, Chengdu
Eligibility
Sex/Gender
All
Age
40 Years to 100 Years
Inclusion criteria
Inclusion criteria: According to the guidelines, CAP is diagnosed as SCAP if it meets 1 major criterion or > = 3 minor criteria. Main Criteria: Requires endotracheal intubation for mechanical ventilation; Sepsis shock requires vasoactive therapy despite aggressive fluid resuscitation. Secondary Criteria: respiratory rate>=30 breaths/min; Arterial partial pressure of oxygen/inspired oxygen concentration=7.14 mmol/L; Systolic blood pressure < 90 mmHg (1 mmHg = 0.133 kPa) requiring aggressive fluid resuscitation. Due to the lack of pulmonary function test results in enrolled patients, the definition of COPD was obtained from the patient's clinical baseline data, and terms including "chronic obstructive pulmonary disease", "emphysema", and "chronic bronchitis" were used as an alternative diagnosis of COPD.
Exclusion criteria
Exclusion criteria: In addition to COPD and severe pneumonia, other respiratory diseases that can cause hypoxia, such as asthma, active tuberculosis, bronchiectasis, interstitial lung disease, pneumothorax, etc.; Prior presence of chronic organ or hematologic dysfunction; Malignancy; Ongoing treatment with immunosuppressant drugs; autoimmune diseases; HIV infection; Greater than or equal to 14 consecutive days of >=20 mg/day prednisolone acetate or equivalent doses of other glucocorticoids or recent receipt of a cumulative dose >of 600 mg of prednisolone acetate or equivalent doses of other glucocorticoids; Acute cardiovascular and cerebrovascular diseases in the past 1 month; Patients who have been hospitalized 2 weeks prior to admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein;28-day cumulative survival;Procalcitonin;fibrinogen;neutrophils;plasma D-dimer; | — |
Secondary
| Measure | Time frame |
|---|---|
| The need for invasive mechanical ventilation;Failure of noninvasive mechanical ventilation; | — |
Countries
China
Contacts
Public ContactMu Shan
Shuangliu District First People’s Hospital, Chengdu
Outcome results
None listed