Bronchus, lung, chest and other diseases
Conditions
Interventions
Traditional sedation PS group (propofol sufentanil combination regimen):High flow humidifying oxygen therapy (45L/min) + sedation program [Sufentanil 1g/kg, propofol 1-2mg/kg titrated to the target se
Midazolam alfentanil combination regimen (MA group):High-flow humidified oxygen therapy (45L/min) + midazolam 0.045mg/kg, and 18mg/kg of afentanil were given at an interval of 1min. If the target seda
Remimazolam Alfentanil Combination (RA Group):High-flow moist oxygen therapy (45L/min) +Remimazolam 0.135mg/kg, and 18mg/kg of afentanil were given at an interval of 1min. If the target sedation depth
Sponsors
Beilun District People's Hospital of Ningbo
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age range 60-85 years 2.ASA grade I - III 3.No other serious systemic complications 4.Conscious and able to cooperate with examination and treatment 5.Patients gave informed consent and signed written informed consent
Exclusion criteria
Exclusion criteria: 1.ASA grade greater than III 2.Patients with chronic alcohol addiction, long-term use of psychotropic drugs (such as sedants) and monoamine oxidase inhibitors 3.Patients with severe liver dysfunction or abnormal renal function (such as preoperative dialysis) 4.Patients with cognitive impairment caused by mental and psychological disorders 5.Patients with bronchial asthma, respiratory depression and myasthenia gravis and high sensitivity 6.Patients with arrhythmia, preoperative left ventricular ejection fraction less than 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats/min), or atrioventricular block of degree II or above
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological test;Sleep assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative hemodynamics;VAS choke score;Hypoxia incidence;Patient resuscitation time;Patient satisfaction and Surgeon satisfaction; | — |
Countries
China
Contacts
Public ContactYunfei Cao
Beilun District People's Hospital of Ningbo
Outcome results
None listed