hypertension
Conditions
Interventions
Rimazzolam group:The induction dose of remifentanil is 6 mg/kg/h for continuous intravenous infusion, with a duration of <= 3 minutes. An additional dose of 12 mg/kg/h is allowed, with an additional d
Propfol group:The induction dose of propofol is 2-2.5mg/kg until consciousness disappears, and the maintenance dose is 4-6mg/kg/h for continuous infusion.
Sponsors
Shenzhen University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria are: 18years old <= age <=65years old; Patients under general anesthesia who have a history of hypertension, ASAII-III grade, and intend to undergo general surgery, exocrine surgery or gynecological surgery (estimated operation time <=3h, intraoperative blood loss <=200 ml).
Exclusion criteria
Exclusion criteria: Exclusion criteria: ASAIV or above (complicated with serious cardiovascular, respiratory and endocrine diseases or complicated with important organ failure); Those who are allergic to the drugs used in this study or have used sedatives for a long time before participating in the study; People with mental illness and cognitive impairment; Pregnant ; Preoperative history of airway diseases such as asthma or sleep apnea; History of myasthenia gravis; History of chronic renal failure and chronic liver damage;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of hypotension (BP90 mmHg) during anesthesia;the frequency of vasoactive drugs;;Total dosage of vasoactive drugs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic data at multiple time points;Median BIS during operation;extubation duration;PACU stay time; | — |
Countries
China
Contacts
Public ContactYanyan Sun
Shenzhen University General Hospital
Outcome results
None listed