End stage diabetes nephropathy
Conditions
Interventions
End-stage renal disease treated with renal transplantation alone:NA
Healthy control group:NA
Diabetes mellitus combined with end-stage renal disease and treated with combined pancreas-kidney transplantation:NA
Sponsors
Second Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. The experimental group was the recipient who receive simultaneous pancreas-kidney transplantation from donation after citizen's death. Control group 1 is the recipient of allogeneic kidney transplantation from donation after citizen's death. Control group 2 is healthy people who have not undergone transplantation; 2. Subjects understand the purpose and risks of the study and are willing to participate in the study and give written informed consent; 3. 18~65 years old, male or female; 4. ABO blood group matching between donor and recipient; 5. Peak PRA < 10%;
Exclusion criteria
Exclusion criteria: 1. The subject has already received organ transplantation; 2. ABO blood group incompatible or T-cell crossmatch positive between donor and recipient; 3. The cold ischemia time of the graft is more than 24 hours; 4. Pre-existing changes in brain function due to non-diabetic factors, such as craniocerebral trauma, cerebrovascular malformations, dementia, and severe cognitive impairment; 5. Poor compliance; 6. Pregnant or breastfeeding women, and women of childbearing age who do not wish to receive contraception; 7. Transplant recipients or donors who are seropositive for HIV; 8. Active systemic infection requiring antibiotic treatment; 9. The patient has a malignant tumour or a history of malignant tumour within the past 5 years, except for non-metastatic basal cell carcinoma of the skin, squamous cell carcinoma, and cervical carcinoma in situ, which have been successfully treated; 10. Subjects with medical or psychiatric conditions affecting compliance;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gray matter volume of the brain;Regional cortical thickness;Montreal Cognitive Assessment score; | — |
Countries
China
Contacts
Public ContactZhang Peng
Second Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed