Knee Osteoarthritis
Conditions
Interventions
Long-course Treatment Group:None
Short-course Treatment Group:None
Medium-course Treatment Group:None
Sponsors
Chengdu Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) KOA patients who met the diagnostic criteria of Chinese Osteoarthritis Diagnosis and Treatment Guideline (2024 edition) and have been diagnosed; 2) Age >=50 years old; 3) The mean visual analogue scale (VAS) of KOA in the last 2 weeks was >=40 mm; 4) Understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) women who plan to become pregnant while pregnant, breastfeeding, or within 3 months; 2) patients who are known to be allergic to this product or other oxib drugs and sulfonamides. 3) patients with asthma, urticaria, or allergic reactions induced by aspirin or other nsaids. 4) patients with hepatic and renal insufficiency. 5) patients with a history of gastrointestinal bleeding or perforation after use of nsaids. 6) patients with active GI ulcer/bleeding or previous recurrent GI ulcer/bleeding. 7) patients with severe heart failure, acute or severe coronary syndrome. 8) perioperative patients undergoing coronary artery bypass grafting (CABG). 9) patients taking medications that may interfere with the evaluation of efficacy (e.g., tricyclic antidepressants, anesthetics, hypnotics, sedatives). 10) other conditions considered by the investigator to preclude participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PASS Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences before and after VAS scores of subjects in each group;The changes of WOMAC pain score, WOMAC function score and PGA score in each group;Effects of arthritis-related proteins and biochemical indices in subjects;The subjects' other laboratory indicators were different before and after comparison;The difference of shedding rate and concept of continuous treatment among all groups during treatment observation; | — |
Countries
China
Contacts
Public ContactLiu Dong
Chengdu Second People's Hospital
Outcome results
None listed