Pediatric tic disorders
Conditions
Interventions
The micro ecological nutrition mixture group:The micro ecological nutrition mixture group took the micro ecological nutrition mixture (8g/strip/time, 2 times/day) for 16 weeks.
The placebo group:The placebo group received maltodextrin at 8g/strip/time, twice a day, for 16 weeks.
Sponsors
the Second Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1.Age 3-10 years old (including 3 and 10 years old), regardless of gender; 2.Patients who met the diagnostic criteria of DSM-V and YGTSS (combined motor tic and vocal tic score, 100 points in total). 3.Patients with mild to moderate TD whose course of disease was more than 3 months and YGTSS score was less than or equal to 50. 4.The medication indications were not met and the parents were unwilling to use medication. 5.The guardian can cooperate to complete the corresponding assessment.
Exclusion criteria
Exclusion criteria: 1.Non autonomous exercisers who can be explained by other diseases, such as rheumatic diseases, Huntington's disease, Wilson's disease, hand foot hyperkinesia, muscle spasms, acute motor disorders, spasms of hysteria, epilepsy and childhood schizophrenia, drug-induced extrapyramidal symptoms, and other extrapyramidal diseases. 2.Children with other unstable or severe heart, lung, liver, kidney, hematopoietic system diseases (including unstable angina, uncontrolled asthma, active gastric bleeding, cancer, etc.); 3.Within one month prior to enrollment, received antibiotics, probiotics, ketogenic diet, fecal microbiota transplantation, proton pump inhibitors, and other treatment plans that affect the gastrointestinal tract, as well as other related TD treatment plans (including any treatment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yale Comprehensive Tourette Syndrome Severity Scale (YGTSS) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Child Behavior Checklist (CBCL) Score;Children's Yale Brown Obsessive Compulsive Scale (CYBOCS) Score;Children's Multidimensional Anxiety Scale (MASC) Score;Children's Depression Inventory (CDI) Score; Gastrointestinal Symptom Rating Scale (GSRS) Score; | — |
Countries
China
Contacts
Public ContactLin Chuhui
the Second Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed