Skip to content

The effect of remifentanil on intraoperative hemodynamics and postoperative cognitive function in elderly hypertensive patients undergoing laparoscopic cholecystectomy

The effect of remifentanil on intraoperative hemodynamics and postoperative cognitive function in elderly hypertensive patients undergoing laparoscopic cholecystectomy

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500100125
Enrollment
Unknown
Registered
2025-04-03
Start date
2025-04-07
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gallstone

Interventions

Test group:Anesthesia induction is performed using injection of remifentanil mesylate (34 mg/vial, Jiangsu Hengrui Pharmaceutical Co., Ltd.), with a physiological saline concentration of 1 mg/mL. Duri
Control group:Anesthesia induction is induced by intravenous injection of propofol 1-1.5 mg/kg, while sufentanil 0.3-0.5 µ g/kg is administered until the patients consciousness disappears (no response

Sponsors

The First People's Hospital of Longquanyi District, Chengdu
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age>=60 years; 2. Patients with a clear diagnosis of hypertension and regular medication, and blood pressure control below 180/110 mmHg; 3. ASAI. ? grade III. patients; 4. Patients who intend to undergo laparoscopic cholecystectomy under general anesthesia; 5. Patients who voluntarily sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. BMI 30 kg/m^2; 2. Accompanied by other serious respiratory and circulatory diseases, severe organ dysfunction; 3. Patients with neurological and psychiatric diseases, language communication disorders and comprehension impairments, and inability to understand the assessment scale; 4. Alcohol or drug dependence; 5. Allergy to the study drug; 6.Participated in other clinical studies within 3 months.

Design outcomes

Primary

MeasureTime frame
Incidence of hypotension during anesthesia induction in two groups of patients;

Secondary

MeasureTime frame
Intraoperative hemodynamic indicators;Anesthesia recovery time index;Score of the Patient's Simplified Mental State Examination Scale in the First 2 Days;

Countries

China

Contacts

Public ContactQiu Deliang

The First People's Hospital of Longquanyi District, Chengdu

95528045@qq.com+86 180 4035 8551

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026