This study was conducted in elderly patients (65 to 80 years old) undergoing carotid endarterectomy (CEA) with a background of atherosclerotic carotid stenosis requiring CEA to prevent ischemic stroke. The central nervous system complications were mainly concerned, including stroke, asymptomatic cerebral infarction and cerebral hyperperfusion syndrome. Postoperative neurocognitive decline (PNCD),
Conditions
Interventions
TaVNS group:Transcutaneous vagal nerve stimulation
StaVNS:Transcutaneous vagus nerve pseudostimulation
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 65-80 years old; 2.ASAI~III grade; 3.Patients undergoing carotid endarterectomy at selected time; 4. No previous history of cerebral infarction and transient ischemic attack; 5.willing to participate in this experiment, sign the informed consent;
Exclusion criteria
Exclusion criteria: 1. Preoperative arrhythmia (bradycardia (HR<55bpm) and conduction block); 2. The skin at the site of vagus nerve is damaged, redness, infection, etc; 3. Severe vision, hearing, or speech problems, unable to complete a neuropsychological assessment; 4. Cognitive impairment (MMSE < 18);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of central nervous system complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality;Occult cerebral infarction;depressed;Cognitive Function Improvement (POCI);Cerebral hyperperfusion syndrome;Stroke;Sleep quality;Cranial nerve injury;Pain VAS scale;anxiety;Postoperative neurocognitive Decline (PNCD);Postoperative delirium; | — |
Countries
China
Contacts
Public ContactMeiyan Zhou
Xuzhou Central Hospital
Outcome results
None listed