Schizophrenia
Conditions
Interventions
Experimental group:HD-tACS stimulation with a GAMA frequency while the patient-healthy dyads performing an interpersonal paradigm (a joint finger tapping task).
Resting control group:HD-tACS stimulation scheme as the experimental group but without a simultaneous behavioral task.
Active control group:HD-tACS stimulation scheme as the experimental group but with a different frequency (theta).
Sham control group:the HD-tACS stimulation is on during the first minute of initiation and the last minute of termination while the participants performing the joint finger tapping task.
Behavioral training group:Intervention only based on the joint finger tapping task.
Sponsors
Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients with schizophrenia: 1.Diagnosed as schizophrenia according to DSM-5 criteria, screened with the Structured Clinical Interview for DSM-5; 2. Possessing at least a junior high school education level (or equivalent); 3. Age 18-50, right handedness; 4. Illness duration =10years; 5. Anti-psychotic naïve or on stable medication with no more than two types of anti-psychotics within at least 2 weeks; 6. No administration of sedatives, stimulants, alcohol, strong tea, coffee, or any psychoactive substances on the day before the experiment. Healthy participants: 1. No history of psychiatric disorders; 2. Possessing at least a junior high school education level (or equivalent); 3. Age 18-50, right handedness; 4. No administration of sedatives, stimulants, alcohol, strong tea, coffee, or any psychoactive substances on the day before the experiment.
Exclusion criteria
Exclusion criteria: Patients with schizophrenia: 1.With a history of head trauma with loss of consciousness, mental retardation, active substance dependence or abuse; have transient ischemic attack, migraine, syncope or other conditions that may affect brain function. 2.Presence of brain tumors, diabetes mellitus, hypertension, cardiovascular diseases, or other severe medical conditions (e.g., infections, allergies). 3.With a history of neurological disorder (including but not limited to epilepsy, multiple sclerosis, etc.). 4.Presence of metallic implants in the cranium or other devices susceptible to external electrical interference (e.g., cranial fixation devices). 5.Patients evaluated as moderate to high risk on the Suicide Risk Assessment Scale (NGASR), had a significant suicidal ideation in the past 12 months, or those deemed to present suicide and violent behavior risks based on clinicians' assessments. 6.Individuals with a history of violent behavior within the past 12 months, those exhibiting highly aggressive tendencies as assessed by the Modified Outcomes Assessment Scale (MOAS) (weighted total score >=4), or those considered potentially threatening to others according to clinical evaluations. 7. Comorbidity with other psychiatric disorders, such as comorbid depressive disorder or bipolar disorder. Healthy participants: 1. With a history of head trauma with loss of consciousness, mental retardation, active substance dependence or abuse; have transient ischemic attack, migraine, syncope or other conditions that may affect brain function. 2. Presence of brain tumors, diabetes mellitus, hypertension, cardiovascular diseases, or other severe medical conditions (e.g., infections, allergies). 3. With a history of neurological disorder (including but not limited to epilepsy, multiple sclerosis, etc.). 4. Presence of metallic implants in the cranium or other devices susceptible to external electrical interference (e.g., cranial fixation devices).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra- and Inter-brain synchrony;Positive and Negative Symptoms;Clinical Global Impression ;Personal and Social Performance;World Health Organization Quality of Life;Cognitive function;Interpersonal behavioral synchronization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depressive symptoms; | — |
Countries
China
Contacts
Public ContactJi Chen
Global Institude of Future Technology, Shanghai Jiao Tong University
Outcome results
None listed