Cardiac surgery associated acute kidney injury in infants
Conditions
Interventions
Experimental group:Patients in the GDP arm will be treated with a GDP strategy, maintaining DO2i = 350 mL/min/m2 during CPB. The primary interventions to achieve this target include increasing the per
Control group:Patients in the control arm will receive arterial pump flow tailored to their body surface area and temperature, within the range of 2.6~3.2 L/min/m2.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
0.1 Years to 3 Years
Inclusion criteria
Inclusion criteria: 1.1month 60min; 5.Written informed consent is available.
Exclusion criteria
Exclusion criteria: 1.Chronic kidney disease (CKD) stage 5 (receipt of kidney replacement therapy or estimated glomerular filtration rate [eGFR] < 15 mL/min/1.73 m2); 2.pre-existing kidney abnormalities; 3.suffering perioperative cardiac arrest; 4.heart transplantation; 5.expected nadir CPB temperature <32?; 6.receiving extracorporeal life support perioperatively; 7.participating in other interventional studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of CSA-AKI; | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of CSA-AKI;30-day postoperative all-cause mortality;Pediatric Intensive Care Unit (PICU) time;Mechanical ventilation time;Hospital stay;Hospital costs;Postoperative 30-day readmission rate;The use and duration of kidney replacement therapy during the hospital stay; | — |
Countries
China
Contacts
Public ContactRonghua Zhou
West China Hospital, Sichuan University
Outcome results
None listed