Depressive and Anxiety Disorders in Adolescents
Conditions
Interventions
Cross-sectional study - Adolescent patients taking sertraline:None
Cross-sectional study - Adolescent patients taking escitalopram:None
Cohort study - Adolescent patients taking sertraline:None
Cohort study - Adolescent patients taking escitalopram:None
Sponsors
Beijing HuiLongGuan Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Study 1: (1) 12-18 years old (including the boundary value), gender is not limited; (2) meet the diagnostic criteria for depressive disorder or anxiety disorder according to ICD-10; (3) currently taking sertraline or escitalopram orally for treatment, and have at least one blood drug concentration data of sertraline or escitalopram, as well as the last dose time and blood collection time. 2.Study 2 and Study 3: (1) 12-18 years old (including the boundary value), gender is not limited; (2) Confirmed by K-SADS-PL, meeting the diagnostic criteria for depressive disorder or anxiety disorder in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) of the United States, either a single episode or recurrent episodes are acceptable; (3) Currently, the total score of MADRS is >= 22 points (for depressive disorder patients) or the total score of the Hamilton Anxiety Scale (HAMA) is >= 20 points (for anxiety disorder patients), and the clinician starts using sertraline or escitalopram; (4) Consent to conduct TDM monitoring of sertraline or escitalopram; (5) Fully understand the study, and the subject and guardian voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Study 1: (1) Other diagnostic conditions that meet ICD-10 criteria, such as bipolar and related disorders, attention deficit hyperactivity disorder, obsessive-compulsive and related disorders, etc.; (2) emotional disorders caused by physical or organic conditions; (3) gastrointestinal disorders or surgical history that may interfere with drug absorption or elimination. 2.Study 2 and Study 3: (1) Confirmed by the K-SADS-PL, other disorders that meet the DSM-5 diagnostic criteria, such as bipolar and related disorders, attention deficit hyperactivity disorder, obsessive-compulsive and related disorders, etc.; (2) Emotional disorders caused by physical illnesses or organic causes; (3) Patients who started or were expected to start systemic psychotherapy, physical therapy, or traditional Chinese medicine within the past 3 months prior to enrollment or within the 8-week follow-up period; (4) Gastrointestinal disorders or surgical history that would interfere with drug absorption or elimination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depressive symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of adverse reactions; | — |
Countries
China
Contacts
Public ContactSong Chen
Beijing HuiLongGuan Hospital
Outcome results
None listed