Effect of Dexmedetomidine Combined with Anterior Approach Sciatic-Femoral Nerve Blocks on Postoperative Recovery Quality in Total Knee Arthroplasty Patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500100098

Enrollment

Unknown

Registered

2025-04-02

Start date

2025-04-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis ?Rheumatoid Arthritis?Other Inflammatory Arthropathies?Traumatic Arthritis

Interventions

General Anesthesia Combined with Nerve Block(A group):Administer normal saline via infusion pump preoperatively

prepare a postoperative analgesia pump.

General Anesthesia with Dexmedetomidine Combined with Nerve Block(B group):Administer dexmedetomidine via infusion pump preoperatively

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.ASA classification: I-III levels; 2.Patients over the age of 18 who have undergone elective total knee arthroplasty in our hospital; 3.Ensure comprehension of the relevant evaluation content; 4.The patient is willing to undergo technical procedures such as sciatic nerve block and femoral nerve block;

Exclusion criteria

Exclusion criteria: 1.Contraindications to nerve block procedures, including but not limited to coagulation disorders, infection at the puncture site, and allergy to local anesthetics; 2.Patients with severe cardiac, hepatic, or renal dysfunction; 3.Patients with neuromuscular disorders, trauma, or concomitant extra-articular pain in the affected limb; 4.Patients with a history of long-term analgesic/sedative medication use or substance abuse; 5.Patients undergoing secondary or subsequent knee revision surgery; 6.Patients with sick sinus syndrome and/or a basal heart rate <50 beats per minute (bpm);

Design outcomes

Primary

Measure	Time frame
Postoperative Recovery Quality Score;	—

Secondary

Measure	Time frame
Hemodynamic indicators at different time points during surgery;Pain score at different time points after surgery;Postoperative sleep scores at different time points;Additional frequency of postoperative patient-controlled analgesia;complication;The time of the first postoperative drop-off;	—

Countries

China

Contacts

Public ContactZhouShuBao

First Affiliated Hospital of Gannan Medical University

zsb1997ren@163.com+86 136 9806 3040

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026