Preterm infants
Conditions
Interventions
INSURE treatment group:None
LISA treatment group:None
Sponsors
International Peace Maternity & Child Health Hospital of China welfare institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preterm infants with gestational age of 25-32 weeks; 2. Continuous non-invasive assisted breathing in the delivery room and during transfer to the neonatal intensive care unit after birth, and no invasive mechanical ventilation was performed at the time of recruitment; 3. Have a clinical indication for pulmonary surfactant therapy, meet one of the following conditions: nasal continuous positive airway pressure (nCPAP) pressure >=6cmH2O, inspired oxygen concentration (FiO2) >0.30, imaging confirmed respiratory distress syndrome (RDS) or rapid disease progression, requiring mechanical ventilation; 4. It is proposed to use LISA or INSURE technology to give surfactant treatment to bovine lung; 5. The child's guardian agrees to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Severe congenital malformations; 2. Severe cyanotic congenital heart disease affecting systemic hemodynamics; 3. Congenital hereditary metabolic diseases; 4. Respiratory distress caused by meconium aspiration; 5. Severe infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of adverse composite outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital mortality;Incidence of bronchopulmonary dysplasia;72-hour invasive mechanical ventilation rate;Total 1-week invasive mechanical ventilation time;Total duration of invasive mechanical ventilation during hospitalization;Duration of assisted ventilation;Secondary drug administration rate;Days of hospitalization;Blood gas indicators;Neonatal complication rate;Duration of oxygen therapy; | — |
Countries
China
Contacts
Public ContactZhiwei Liu
International Peace Maternity and Child Health Hospital of China Welfare Institution
Outcome results
None listed