Alzheimers disease
Conditions
Interventions
Healthy older adults without cognitive impairment:NA
Mild AD patients:NA
amnestic mild cognitive impairment, aMCI:NA
Moderate AD patients:NA
Sponsors
the first hospital of hebei medical university
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Subjects with informed consent are 45 years old (inclusive) to 85 years old (inclusive) at the time of signing the informed consent form, right-handed; 2. Meets diagnostic criteria for Alzheimer's disease(AD) or mild cognitive impairment (MCI): (1) Alzheimer's disease: meet the core clinical criteria of probable AD dementia in the 2011 NIA-A revised diagnostic criteria for AD. (2) mild cognitive impairment: Peterson's diagnostic criteria for MCI in 2014; 3. Neuropsychological score: MMSE <=28 points, Clinical dementia score: CDR <=2 points. 4. Cognitive comprehension ability to cooperate with the measurement of eye movements.
Exclusion criteria
Exclusion criteria: 1. Those who have a history of alcohol intoxication, or a history of drug addiction, or neurological diseases other than AD that can cause cognitive impairment, such as brain trauma, epilepsy, encephalitis, and normal intracranial pressure hydrocephalus; 2. Systemic diseases that may lead to mild to moderate dementia (such as liver and kidney insufficiency, endocrine diseases, vitamin deficiencies); 3. Those with severe aphasia or physical disability who are unable to complete neuropsychological examination; 4. Accompanied by eye diseases, such as glaucoma, cataract, blurred vision or loss of visual field. 5. Patients who took amantadine, diazepam or levodopa in the past three months and complained of visual hallucinations; 6. Accompanied by eye diseases, such as glaucoma, cataracts, blurred vision or loss of visual field. 7. Patients who took amantadine, diazepam or levodopa in the past three months and complained of visual hallucinations; 8. The researchers think it is not suitable for participants in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological scale score;Reaction time;Degree of brain activation;Correct rate of response;Reaction time;Reaction rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fixed number of year of the education; | — |
Countries
China
Contacts
Public ContactQiu Huiqing
the first hospital of hebei medical university
Outcome results
None listed