Primary cutaneous amyloidosis
Conditions
Interventions
Experimental group:Tofacitinib 5mg bid
Sponsors
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. The patient is between 18-65 years old; 2. The skin lesions meet the clinical diagnostic criteria for LA and MA; 3. After pathological examination, it meets the pathological diagnostic criteria of PCA: that is, uniform and unstructured eosinophilic substances are seen in HE staining, and metachromatic reaction is seen in crystal violet staining, which is purple-red; 4. No use of corticosteroids, immunosuppressants and JAK inhibitors, such as baricitinib and abuxitinib, in the past 3 months.
Exclusion criteria
Exclusion criteria: 1. Other types of cutaneous amyloidosis; 2. Pregnant and lactating women; 3. Have had a severe allergic reaction, or have a known allergy to JAK inhibitors; 4. Severe neurological and psychiatric diseases, endocrine and metabolic system diseases, connective tissue diseases; 5. History of major surgery in the past 8 weeks, infection in the past 12 weeks, mainly including bacterial and viral infections, such as lung infection, shingles, chickenpox, erysipelas and cellularity, etc.; 6. Suffering from hematologic diseases, such as myelodysplastic syndrome, trilineage hypoplasia, etc.; 7. Positive for hepatitis B surface antigen and HBV-DNA; 9. Evidence of latent tuberculosis or active tuberculosis, including evidence of tuberculosis on lung CT, positive T-SPOT, etc.; 9. Suffering from malignant neoplastic diseases; 10. Severe hepatic and renal insufficiency; 11. Have a history of drug abuse, alcoholism, or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extent of lesions;Pruritus Numeric Rating Scale score;Dermatology quality of life questionnaire results;Lesion severity score; | — |
Countries
China
Contacts
Public ContactCao Yuchun
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed