Acute coronary syndrome
Conditions
Interventions
SGLT2 inhibitor group:SGLT2 inhibitors
Control group:Usual care
Sponsors
Xi'an Jiaotong University Second Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The age of the patients ranged from 18 to 80 years; 2.Patients diagnosed with unstable angina, non-ST-segment elevation myocardial infarction, or ST-segment elevation myocardial infarction who underwent coronary intervention (including stent or drug-balloon implantation) within 72 hours; 3.The informed consent to participate in this clinical trial was signed.
Exclusion criteria
Exclusion criteria: 1.Diabetes; 2.The patient had a history of chronic heart failure or had a left ventricular ejection fraction <= 40% before admission; 3.cardiogenic shock; 4.Renal insufficiency (glomerular filtration rate < 30 mL/min/1.73 m^2); 5.Hypoglycemia, acidosis, hepatic insufficiency; 6.Previous or planned coronary-artery bypass grafting; 7.They were currently receiving an SGLT2 inhibitor or had received an SGLT2 inhibitor within 4 weeks before enrollment; 8.Pregnancy, lactation, a history of cancer within the previous 3 years, autoinflammatory conditions, current or planned long-term treatment with systemic glucocorticoids, acute symptomatic urinary tract infection or genital infection, or clinically significant nontransient hematologic disorders; 9.Patients with contraindications to SGLT2 inhibitors;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major adverse cardiovascular and cerebrovascular events (the sum of events of myocardial infarction, heart failure, stroke, all-cause death, cardiovascular death, hospitalization for heart failure, and all-cause hospitalization); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac structural and functional indicators (including pro-brain natriuretic peptide, left ventricular end-diastolic diameter, left ventricular ejection fraction, etc.);4 w, 12 w, 6 months and 12 months; | — |
Countries
China
Contacts
Public ContactChen Guo
Xi'an Jiaotong University Second Affiliated Hospital
Outcome results
None listed