Vitiligo
Conditions
Interventions
Progressive Vitiligo group:Peripheral blood
Control:Peripheral blood
Vitiligo group:Skin lesion tissues and blister fluid (500 µL) from the white patches of patients with progressive vitiligo
Control:Skin tissue and blister fluid (500 µL) from normal control subjects
Sponsors
The Third Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Normal physical examination patients and patients with advanced vitiligo; 2. The inclusion criteria of patients with advanced vitiligo refer to the consensus on the diagnosis and treatment of Vitiligo (2021 edition); 3. The progressive stage was determined by Vitiligo disease activity score (VIDA), homotypic response, and Wood lamp. VIDA score: new or original skin lesions within the past 6 weeks (+4 points), new or original skin lesions within the past 3 months (+3 points), new or original skin lesions within the past 6 months (+2 points). New skin lesions or enlargement of original skin lesions in the past year (+1 score); The total score > 1 was defined as progressive stage, and > =4 was defined as rapid progressive stage. Isomorphous reaction: local leukoplakia within 1 year after skin injury; Wood's lamp: the color of the lesion was grayish-white, the boundary was unclear, and the area of the lesion under Wood's lamp was larger than the visual area, suggesting a progressive stage.Progression of the disease could be considered if any of the above three factors were met.
Exclusion criteria
Exclusion criteria: None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HIF-1a;Inducible nitric oxide synthase, iNOS;The enzyme catalase, CAT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nitric oxide, NO;Malondialdehyde, MDA;Superoxide dismutase, SOD; | — |
Countries
China
Contacts
Public ContactYan Cao
The Third Affiliated Hospital of Nanjing Medical University
Outcome results
None listed