Menopausal syndrome after oophorectomy in reproductive-age patients
Conditions
Interventions
Control group:After skin incision, intravenous infusion of 0.3 mg/kg/h normal saline until the end of surgery
Experimental group:After skin incision, intravenous infusion of 0.3 mg/kg/h esketamine until the end of surgery
Sponsors
Obstetrics and Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Age between 25 and 55 years old; 2. Bilateral oophorectomy under general anesthesia for endometrial cancer resection; 3. American Society of Anesthesiologists (ASA) physical status classification ? to ?; 4. Premenopausal status preoperatively without obvious menopausal symptoms (Kupperman score <=6); 5. No hormonal therapy used within 6 months preoperatively; 6. Willing to participate in this study and accept complete postoperative follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients with malignant tumors in other sites; 2. Patients who have received radiotherapy or chemotherapy preoperatively; 3. Patients with contraindications to esketamine; 4. Patients with a history of esketamine abuse or dependence; 5. Patients with communication disorders or difficulty understanding the assessment scales used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Kupperman Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Follicle-stimulating hormone;Estradiol;Anti-Mullerian hormone;TNF-a,Tumor necrosis factor a;IL-6;BDNF,Brain-derived neurotrophic factor;5-HT; | — |
Countries
China
Contacts
Public ContactShen Sun; Wang Zizhu
Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University
Outcome results
None listed