Actinic Cheilitis
Conditions
Interventions
Control group:Vaseline treatment
Test group:Treatment using Vaseline containing membrane vesicles derived from Rothia mucilaginosa
Sponsors
The Third Affiliated Hospital of PLA Air Force Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Male participants aged 18-40 years; 2. In good general health and available for examinations throughout the trial period; 3. Actinic cheilitis classified as Grade II or above according to the Rubem clinical grading criteria (AC Grade I: Dryness and desquamation of the lip vermilion; AC Grade II: Atrophy of the lip vermilion, pallor, accompanied by erosion; AC Grade III: Hyperkeratosis of the lip vermilion, rough desquamation, with spread of the lesion to the oral mucosa or perioral skin; AC Grade IV: Ulceration or leukoplakia occurring at one or more sites of the lips); 4. Voluntary participation and signing of an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Participants have other severe oral, skin, or systemic diseases; 2. Currently or within the past month, received cheilits medications, surgery, or laser therapy; 3. Within one month before participating in the study, use of the following medications: hormonal medications, immunosuppressants, antihistamines, antibiotics, sedatives, etc; 4. A history of allergies to food, medications, cosmetics, or probiotic preparations, or a history of idiosyncratic reactions; 5. Participation in other clinical trials within the past month; 6. Habits of smoking, betel nut chewing, gum chewing, or alcohol consumption.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lip vermilion Trans-Epidermal Water Loss (TEWL);Actinic cheilitis clinical grade; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete blood count;Serum C-reactive protein concentration;Liver function test;Kidney function test; | — |
Countries
China
Contacts
Public ContactKun Xuan
Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University.
Outcome results
None listed