ISS
Conditions
Interventions
rhGH group:None
Sponsors
People's Hospital of Ningxia Hui Autonomous Region
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Pre - puberty, Tanner stage I; 2.For boys, the bone age is less than 10 years old; for girls, the bone age is less than 9 years old, and the difference between the bone age and the chronological age does not exceed 3 years; 3.The height is lower than the mean height of normal children of the same race, age, and gender by - 2.0 SDS or lower than the third percentile level; 4.The parents of the children are informed and voluntarily participate in this research.
Exclusion criteria
Exclusion criteria: 1.Pubertal development (Tanner stage greater than or equal to stage II); 2.Patients diagnosed with other types of growth and development abnormalities, such as growth hormone deficiency (GHD), Turner syndrome, Noonan syndrome, Laron syndrome, growth hormone receptor deficiency, small for gestational age with short stature, and growth and development retardation caused by malnutrition; 3.Patients with dysfunction of important organs such as the liver and kidneys; 4.Patients with congenital skeletal development abnormalities; 5.Patients with central nervous system diseases or organic diseases; 6.Patients expected to use recombinant human growth hormone (rhGH) for less than 1 year; 7.Patients who are deemed unsuitable for inclusion after being evaluated by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IGF-125(OH)DHtSDS;;25(OH)D;HtSDS; | — |
Countries
China
Contacts
Public ContactYe Yanhong
People's Hospital of Ningxia Hui Autonomous Region
Outcome results
None listed