Metabolic associated fatty liver disease
Conditions
Interventions
Sedentary group:None
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the exercise group: 1. Voluntary signing of informed consent; 2. Age 18-30 years old; 3. Male or female; 4. BMI 18.5-24 kg/m^2; 5. No less than 3 times per week of moderate-intensity to high-intensity exercise (i.e., the average heart rate of exercise is not less than (220-age) multiplied by 0.6 beats/min) in the preceding 3 months, with a total duration of exercise of no less than 150 minutes; Inclusion criteria for sedentary group: 1. Voluntary signing of informed consent; 2. Age 18-30 years old; 3. Male or female; 4. BMI 18.5-24 kg/m^2; 5. Long-term sedentary behavior in the previous 3 months without any exercise habit.
Exclusion criteria
Exclusion criteria: 1. Those who have taken hormones within 3 months; 2. Those who have taken oral antibiotics within 1 month; 3. Have taken drugs that may interfere with glucose and lipid metabolism (e.g. insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin sodium, etc.) and drugs that affect intestinal flora, such as probiotics and Chinese herbs, in the past 1 month; 4. Heavy alcohol consumption (more than 30g of alcohol per day for men and more than 20g of alcohol per day for women) for more than 6 months; 5. Combined acute and chronic hepatitis and cirrhosis; 6. Combined chronic inflammatory diseases of the intestinal tract, acute infections; 7. Combined malignant tumors or other serious diseases; 8. Those who are losing weight; 9. Pregnant and lactating women; 10. Cardiac and renal insufficiency; 11. Persons with mental disorders; 12. In the judgment of the investigator, participation in this study is deemed unsuitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbiota in feces; | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolites in blood and feces; | — |
Countries
China
Contacts
Public ContactSun Jian
Southern Medical University Southern Hospital
Outcome results
None listed