Postoperative pulmonary complications
Conditions
Interventions
Experimental group:1.Choose the left ear nail as the stimulation site
2.First, clean the left ear canal and ear nail with an alcohol tablet, and then wipe the skin with water to keep it moist. It is a
4.Stimulation was given for 20 minutes after anesthesia induction, 20 minutes per hour until the end of the operation after the start of the operation, 20 minutes after entering the anesthesia recover
Stimulation intensity: 3mA
Pulse width 200us
Pulse pause ratio (duty cycle) 30s:30s. Heart rate and SaO2 were monitored during stimulation
Control group:1.Choose the left ear nail as the stimulation site
2.First, clean the left ear canal and ear nail with an alcohol tablet, and then wipe the skin with water to keep it moist. It is also p
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Male or female aged 60 years or older; 2.Preoperative anesthetic assessment : ASA grade II-III; 3.Upper abdominal surgery(hepatectomy, pancreaticoduodenectomy, gallbladder/duct cancer surgery, pancreatic cancer surgery, gastric cancer surgery) and the duration of surgery >= 3 hours; 4.The mode of anesthesia is general anesthesia; 5.The patient understands the research content, voluntarily participates, and signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Long-term preoperative continuous ventilatory support (CPAP/BiPAP) or oxygen dependence; 2. Pheochromocytoma; 3. Patients with epilepsy, cognitive dysfunction (MMSE score) and those who cannot cooperate; 4. Preoperative combination of heart, lung, and kidney dysfunction is as follows (1) NYHA cardiac function class>=III; conduction block and/or severe ventricular dysfunction; (2) Preoperative COPD, asthma and/or pulmonary infection; SaO2 = 90% when inhaling air in a calm state<=90%; (3) eGFR<=60 ml/min 80 ml/min; Patients requiring intermittent renal dialysis. 5. Contraindications to taVNS (placement of pacemakers, cochlear implants or implanted or other electronic devices, etc.); 6. Patients taking anticholinergic drugs before surgery; 7. Suffering from skin diseases in the left ear area; 8. Those who plan to undergo left internal jugular vein catheterization; 9. Investigators who have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of pulmonary complications within one week postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bedside pulmonary function;Arterial blood gases;acetylcholine;Interleukin-6;Interleukin-1ß;Tumor necrosis factor-a;Interleukin-10;C-reactive protein;High mobility group box 1 protein;Duration of postoperative oxygen therapy;Length of postoperative hospital stay;Total length of hospital stay;Liver function;Kidney function;Visual analogue score for pain;Delirium assessment;Incidence of other postoperative adverse events; | — |
Countries
China
Contacts
Public ContactJianteng Gu
The First Affiliated Hospital (Southwest Hospital) of Army Medical University
Outcome results
None listed