schizophrenia
Conditions
Interventions
Experimental group:IM Ziprasidone
Control group:IM Haloperidol
Sponsors
Shandong Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Inpatients who meet the diagnostic criteria for schizophrenia according to ICD-10, aged between 18 and 60 years, with no restrictions on gender; 2.PANSS-EC score = 15 points, with at least one item = 5 points; 3.ACE (Agitation-Calm Rating Scale) score = 3 points; 4.Approval from the Ethics Committee of Shandong Provincial Mental Health Center, and written informed consent obtained from the patient or their legal guardian.
Exclusion criteria
Exclusion criteria: 1. alcohol and/or substance abuse; 2.a previous diagnosis of another mental disease; 3. thyroid illness, gout, kidney disease, major organic brain disease, immune disease, diabetes, etc.; 4.an infection in the previous 4 weeks or use of anti-inflammatory drugs, antibiotics, or glucocorticoids; 5. breastfeeding or pregnant; 6. regular use of psychiatric drugs in the past 2 weeks; 7. validated clinical significant abnormal laboratory values; 8.QTc prolongation or a prodrug QTc over or equal to 450 milliseconds; 9.known allergy to ziprasidone or haloperidol; 10.those who were treated with electroconvulsive therapy during the previous 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale;Excitement Factor of Positive and Negative Syndrome Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Agitation-Calm Rating Scale;Behavioral Activity Rating Scale;Electrocardiogram;Blood Routine Examination;C-reactive protein; | — |
Countries
China
Contacts
Public ContactQi Sufang
Shandong Mental Health Center
Outcome results
None listed