Alzheimers disease (AD) is one of the major diseases that endanger the health of the elderly. Pathological phenomena such as senile plaques formed by the deposition of a large amount of ß-amyloid (Aß) outside the brain nerve cells, intracellular neurofibrillary tangles (NfTs) formed by abnormal phosphorylation of pottery protein, neuronal loss, neurodystrophy, synaptic loss and so on.
Conditions
Interventions
Observation group 1 [There were 50 cases of AD, 50 cases of MCI, 50 cases of normal cognitive function, and 50 cases of interference term (20 cases of vascular dementia, 20 cases of PD, 5 cases of fro
Observation group 2 [There were 50 cases of AD, 50 cases of MCI, 50 cases of normal cognitive function, and 50 cases of interference term (20 cases of vascular dementia, 20 cases of PD, 5 cases of fro
Sponsors
the first hospital of hebei medical university
Eligibility
Sex/Gender
All
Age
55 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1.Alzheimer's Disease Inclusion Criteria: (1) Over 55 years old (2) Obvious abnormal findings or cognitive impairment in neuropsychological tests: MMSE score (Mini-mental State Examination) is less than 20 points (3) Amyloid PET examination found pathological changes related to cognitive impairment (4) According to the diagnostic criteria for AD from the National Institute on Aging and the Alzheimer's Association (NIA-AA), the diagnosis of AD dementia was made 2.MCI (Mild Cognitive Impairment) Inclusion Criteria: (1) Over 55 years old (2) Obvious abnormal findings or cognitive impairment found in neuropsychological tests: MMSE score (Mini-mental State Examination) between 24 and 30 points (3) Amyloid PET examination found pathological changes related to cognitive impairment (4) According to the diagnostic criteria of the National Institute on Aging and the Alzheimer's Association (NIA-AA) for MCI, the diagnosis of MCI dementia was confirmed. 3.Inclusion Criteria for Persons with Normal Cognitive Function: (1) Over 55 years old (2) No obvious abnormal findings or cognitive impairment were found in the neuropsychological test: the MMSE score (Mini-mental State Examination) was above 27 points (3) No pathological changes related to cognitive impairment were found in amyloid PET examination (4) No history of major neurological diseases or psychiatric diseases (5) No history of cardiovascular and cerebrovascular diseases Vascular dementia, PD, frontotemporal dementia, dementia with Lewy bodies Inclusion Criteria: Enrollment was made according to their respective clinical diagnostic criteria.
Exclusion criteria
Exclusion criteria: 1. Cancer patients; 2. People who have participated in clinical trials of other drugs within 30 days;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| multimodal combination; | — |
Countries
China
Contacts
Public ContactMaXiaowei
the first hospital of hebei medical university
Outcome results
None listed