Liver Transplantation
Conditions
Interventions
Test group:Enteric-Coated Mycophenolate Sodium (EC-MPS) Monotherapy
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. At least 6 months after liver transplantation, the liver function is stable and the renal function is abnormal, higher or lower than normal values (including creatinine, cystatin C, ß2 microglobulin, eGFR, urine protein, urea nitrogen, uric acid, etc.) 2. Liver transplant recipient >= 18 years old 3. Using CNI-based immunosuppressive regimens prior to study entry 4. The pregnancy test is negative
Exclusion criteria
Exclusion criteria: 1. A second liver transplant is performed for various reasons within 1 year after the first transplant; 2. Patients with serious underlying diseases, including heart disease, infection and renal insufficiency, combined with other malignant tumors; 3. Active hepatitis B or C (transaminases more than three times the upper limit of normal or total bilirubin more than twice the upper limit of normal, HBV DNA or HCV RNA replication); 4. Leukopenia ( 4.0 mg/dL, eGFR <= 45 mL/min.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute rejection;Adverse events; | — |
Countries
China
Contacts
Public ContactWenzhi Guo
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed